Time-delayed onset of oxidative phosphorylation induced by nucleotide analogs
نویسندگان
چکیده
منابع مشابه
In vivo Analysis of H2AX Phosphorylation Induced by γ-Radiation
ABSTRACT Background and Objectives: Exposure to ionizing radiation in modern societies is inevitable and can cause a variety of adverse health effects such as cancer and birth defects. Therefore, a reliable, repeatable and sensitive method is required for evaluation of radiation exposure. The aim of this study was to determine the amount of hist...
متن کاملDelayed-onset vemurafenib-induced panniculitis
INTRODUCTION Approved in 2011, vemurafenib is a selective serine/threonine kinase inhibitor directed against the V600E mutation in the BRAF gene. This drug is often used in dermatology as a targeted therapy for metastatic or unresectable melanomas, for which about 50% have this mutation. Other tumors possessing the V600E mutation are targets for this therapy. The commonly reported adverse effec...
متن کاملStructural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.
Successive phosphorylation of nucleoside analog prodrugs to their triphosphate forms is required for the pharmacological activity of these compounds in the chemotherapeutic treatment of viral infections and cancer. Human thymidylate kinase (TMPK), apart from its essential physiological role in the biosynthesis of TTP, is also required for the activation of thymidine analogs, such as the clinica...
متن کاملDelayed-Onset Hepatic Encephalopathy Induced by Zolpidem: A Case Report
Hepatic encephalopathy (HE) is a complex neuropsychiatric disorder associated with either hepatocellular insufficiency and/or the presence of porto-systemic shunts. It is thought to be induced by altered neurotransmission mediated by enhanced gamma-aminobutyric acid (GABA)-induced inhibitory tone. The use of benzodiazepines are generally avoided in patients with advanced chronic liver disease (...
متن کاملPerception of sine-wave analogs of voice onset time stimuli.
It has been argued that perception of stop consonant voicing contrasts is based on auditory mechanisms responsible for the resolution of temporal order. As one source of evidence, category boundaries for nonspeech stimuli whose components vary in relative onset time are reasonably close to the labeling boundary for a labial stop voiced-voiceless continuum. However, voicing boundaries change con...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: FEBS Letters
سال: 1981
ISSN: 0014-5793
DOI: 10.1016/0014-5793(81)80884-8